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CAS # 108-98-5


Thiophenol is an organosulfur compound with the formula C6H5SH, sometimes abbreviated as PhSH. This foul-smelling colorless liquid is the simplest aromatic thiol. The chemical structures of thiophenol and its derivatives are analogous to phenols except the oxygen atom in the hydroxyl group (-OH) bonded to the aromatic ring is replaced by a sulfur atom. The prefix thio- implies a sulfur-containing compound and when used before a root word name for a compound which would normally contain an oxygen atom, in the case of thiol that the alcohol oxygen atom is replaced by a sulfur atom.


AppearanceColorless liquid
OdorUnpleasant, pungent
Density1.0766 g/mL
Melting point−15 °C (5 °F; 258 K)
Boiling point169 °C (336 °F; 442 K)
Solubility in water0.08%[2]
SolubilityMost organic solvents; aqueous base
Vapor pressure1 mmHg (18°C)[2]
Acidity (pKa)

6.62 (H2O)

10.28 (DMSO)

Magnetic susceptibility (χ)-70.8·10−6 cm3/mol


  • Thiophenols are used in the production of pharmaceuticals including of sulfonamides. The antifungal agents butoconazole and merthiolate are derivatives of thiophenols.